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[중년의뇌] Exercise-induced neurogenesis

by 변정구 posted Apr 03, 2011
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첨부된 pdf파일은 중년의뇌, 200페이지에 나오는
2007년 봄에 발표된, 스콧 스몰(Scott Small)의 연구 논문입니다.

결론 :
운동(exercise)이 선택적으로 치아이랑(dentate gyrus)의 신경세포 생성(neurogenesis)을 촉진한다.
운동이 기억력을 향상시킨다
운동이 뇌의 힘을 증폭시킨다.





Fig. 1. Exercise selectively increases dentate gyrus CBV in mice. 
(Left) High-resolution MRI slice that visualizes the external morphology and internal architecture
of the hippocampal formation.
(Center) Parcellation of the hippocampal subregions (green, entorhinal cortex; red, dentate gyrus; dark blue, CA3 subfield; light blue, CA1 subfield).
(Right) Hippocampal CBV map (warmer colors reflect higher CBV).


Fig. 2. Exercise-induced increases in dentate gyrus CBV correlate with neurogenesis. 
As shown by confocal microscopy, the majority of the new cells were colabeled with NeuN
(red, BrdU labeling; green, NeuN;yellow, BrdU/NeuN double labeling).


Fig. 3. Exercise selectively increases dentate gyrus CBV in humans. 
High-resolution MRI slice that visualizes the external morphology and internal architecture of the hippocampal formation.
(Center) Parcellation of the hippocampal subregions
(green, entorhinal cortex; red, dentate gyrus; blue, CA1 subfield; yellow, subiculum).
(Right) Hippocampal CBV map (warmer colors reflect higher CBV).


(참고)
CBV : cerebral blood volume

Scott Small
http://www.cumc.columbia.edu/dept/taub/fas/small.html

hippocampus
http://en.wikipedia.org/wiki/Hippocampus