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  • ?
    김제원 2011.02.24 02:41
    최신 정보네요.

    첫 링크는 영어, 두번재 링크는 한글 기사(거의 원문과 동일한 내용)네요.
    (첫번째 열심히 읽고, 두번째 열었더니 한글이네요.)

    시간 없으신 분들은 두번째 링크로 보심 되겠네요.

    요약 : axon에서도 firing이 일어나고, axon 끼리도 talk 한다.
    (기존의 뉴런에 대한 지식과 다른 참신한 발견이다.)
  • ?
    변정구 2011.02.24 02:41
    Slow integration leads to persistent action potential firing in distal axons of coupled interneurons - pp200 - 207
    Mark E J Sheffield, Tyler K Best, Brett D Mensh, William L Kath & Nelson Spruston
    doi:10.1038/nn.2728
    Absrtact
    The conventional view of neurons is that synaptic inputs are integrated on a timescale of milliseconds to seconds in the dendrites, with action potential initiation occurring in the axon initial segment. We found a much slower form of integration that leads to action potential initiation in the distal axon, well beyond the initial segment. In a subset of rodent hippocampal and neocortical interneurons, hundreds of spikes, evoked over minutes, resulted in persistent firing that lasted for a similar duration. Although axonal action potential firing was required to trigger persistent firing, somatic depolarization was not. In paired recordings, persistent firing was not restricted to the stimulated neuron; it could also be produced in the unstimulated cell. Thus, these interneurons can slowly integrate spiking, share the output across a coupled network of axons and respond with persistent firing even in the absence of input to the soma or dendrites.
    http://www.nature.com/neuro/journal/v14/n2/full/nn.2728.html

    The Spruston Lab
    http://groups.nbp.northwestern.edu/spruston/
  • ?
    김향수 2011.02.24 02:41
    아 그래서 역발상이 가능한가~!?